Hu antibody

Hu antibody


HU ANTIBODY

Neuroimmunolgy
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Neuro-antibodies
- Paraneoplastic antibodies
- PND and cerebellum
- Yo antibody
- Hu antibody
- Ri antibody
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- GAD antibody
- MAG antibody
- CV2 antibody
- Amphiphysin antibody

Neuromuscular antibody
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Neurological cases
- Contents
- Clinical Case 1: Atypical PCA
- Clinical Case 2: Ma
- Clinical Case 3: Tr
- Clinical Case 4: Masked Hu
- Clinical Case 5: CNS infection

Uncharacterised patterns
- Granular Layer
- Mitonchondrial
- Neuronal nuclei
- Neuronal Nuclear Rim
- Resembles Yo
- Resembles MAG
- Atypical PCA
- Sarcolemma

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Neuroimmunology: Anti-Hu (ANNA1) antibody on cerebellum.

Associated tumour: Small cell lung carcinoma and neuroblastoma
Neurological syndrome: Cerebellar ataxia, Paraneoplastic encephalomyelitis/sensory neuropathy

IgG binds to cell nuclei of the central and peripheral neurones. Antibody to ANA must be eliminated.

Primate cerebellum showing binding to the granular and Purkinje neurones. These findings must be supported by Western blot (see below).

Rodent stomach: Anti-Hu antibody staining myenteric plexus.

Western blot: Hu antibody binds to 38 kDa protein.

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