GAD

GAD


GAD

Neuroimmunolgy
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- GAD antibody
- MAG antibody
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Neurological cases
- Contents
- Clinical Case 1: Atypical PCA
- Clinical Case 2: Ma
- Clinical Case 3: Tr
- Clinical Case 4: Masked Hu
- Clinical Case 5: CNS infection

Uncharacterised patterns
- Granular Layer
- Mitonchondrial
- Neuronal nuclei
- Neuronal Nuclear Rim
- Resembles Yo
- Resembles MAG
- Atypical PCA
- Sarcolemma

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Neuroimmunology: Anti-GAD antibody.

Associated tumours: Breast, colon, small cell lung carcinoma
Neurological syndrome: Stiff person’s syndrome or diffuse hypertonia. GAD has also been reported in cerebellar ataxia, epilepsy and myoclonus.

Click on images for full size.

GAD antibody on primate pancreas (Islet cell antibody has similar distribution). The target antigens are GAD 67 and GAD 65 which are associated with Stiff-man syndrome and insulin dependent diabetes mellitus respectively.

Low magnification: GAD staining the granular layer in the primate cerebellum. In contrast to amphiphysin there is a lack of staining in the molecular layer.

Higher magnification of the granular cells showing GAD reactivity.

Email: A.R.Karim@bham.ac.uk
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